蛋白质抑制可以削弱白血病细胞

发布时间：2026-04-10来源：D-Pharm

In a study conducted by the Mainz University Medical Center,

在美因茨大学医学中心进行的一项研究中，

cancer

癌症

cells in

细胞在

acute myeloid leukemia

急性髓系白血病

were specifically weakened by a newly discovered mechanism. The inhibition of certain proteins that influence gene activity triggered a strong immune response in the cancer cells. This immune response resembled that of influenza, weakened the tumor cells and could trigger their

被一种新发现的机制特别削弱。抑制某些影响基因活动的蛋白质触发了癌细胞的强烈免疫反应。这种免疫反应类似于流感，削弱了肿瘤细胞，并可能触发它们的

cell death

细胞死亡

. The researchers were even able to enhance this effect with immunostimulatory messenger substances. In the long term, the results could contribute to the development of a new, targeted combination therapy for acute myeloid

研究人员甚至能够通过免疫刺激信使物质增强这种效果。从长远来看，这些结果可能有助于开发一种针对急性髓性白血病的新的、有针对性的联合疗法。

leukemia

白血病

. The results were published in the journal

。研究结果发表在期刊上

Blood

血液

。

Microscopic image of cancer cells of acute myeloid leukemia (400x magnification)

急性髓系白血病癌细胞的显微图像（400倍放大）

版权: UM/Canva

Acute myeloid leukemia (AML) is an aggressive form of blood cancer. It develops when precursor cells of blood cells multiply uncontrollably in the bone marrow, where blood cells are formed. These non-functional cells displace the healthy blood cells, resulting in a shortage of blood cells and platelets.

急性髓系白血病（AML）是一种侵袭性的血癌。它发生在血细胞的前体细胞在骨髓中不受控制地增殖时，而骨髓是血细胞形成的地方。这些非功能性的细胞取代了健康的血细胞，导致血细胞和血小板的短缺。

As a result, oxygen transport, blood clotting and the immune defense function only to a limited extent..

因此，氧气运输、血液凝固和免疫防御功能仅在有限程度上发挥作用。

A research team led by Dr. Daniel Sasca, Head of Personalized Hematology and Medical Oncology at the Department of Medicine III of the Mainz University Medical Center, has investigated how the inhibition of the two proteins p300 and CBP affects tumor cells. These two proteins act like control centers and control which genes are switched on and off in a cell..

由美因茨大学医学中心第三内科个性化血液学和肿瘤学主任丹尼尔·萨斯卡博士领导的研究团队，研究了抑制p300和CBP这两种蛋白质如何影响肿瘤细胞。这两种蛋白质如同控制中心，调控着细胞中哪些基因被开启或关闭。

Until now, researchers have assumed that the inhibition of p300 and CBP generally attenuates the activity of genes. However, the results of the study 'Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML' showed the opposite: in some of the cancer cells, the protein inhibition switched on certain defense programs.

到目前为止，研究人员一直认为抑制 p300 和 CBP 通常会减弱基因的活性。然而，研究《抑制 p300/CREBBP 催化活性在急性髓系白血病中引发依赖于环境的转录激活》的结果却显示了相反的情况：在某些癌细胞中，蛋白质抑制反而开启了特定的防御程序。

This in turn activated genes that are normally involved in the immune defense against viral infections. This immune response caused the cancer cells to stop growing, change and eventually die. 'We see a kind of false alarm inside the cancer cells,' explains Dr. Sasca, who led the study. 'The tumor cells get a severe flu from our therapy and die as a result.'.

这反过来激活了通常参与抗病毒免疫防御的基因。这种免疫反应导致癌细胞停止生长、发生改变并最终死亡。领导这项研究的萨沙博士解释说：“我们看到癌细胞内部出现了一种假警报。肿瘤细胞因我们的治疗而患上严重的流感，并因此死亡。”

The researchers were even able to specifically enhance this effect: In combination with interferon-alpha, an endogenous antibody against viruses and tumors, the cancer cells reacted particularly sensitively. Both in cell cultures and in animal models, the combination therapy had a significantly stronger effect against leukemia..

研究人员甚至能够特别增强这种效果：与干扰素-alpha（一种针对病毒和肿瘤的内源性抗体）结合使用时，癌细胞的反应尤为敏感。无论是在细胞培养还是动物模型中，这种组合疗法对白血病都显示出显著更强的效果。

The researchers investigated this mechanism at several levels of gene regulation simultaneously: from gene activity and protein changes to the DNA-protein complex. The researchers used modern biochemical analysis methods, such as single cell examinations, proteome analyses and genetic test procedures.

研究人员同时在基因调控的多个层面上研究了这一机制：从基因活性和蛋白质变化到DNA-蛋白质复合物。研究人员使用了现代生物化学分析方法，如单细胞检测、蛋白质组分析和基因测试程序。

This enabled the scientists to observe the reaction of the leukemia cells to the inhibition of p300 and CBP from several angles simultaneously. The results of this basic research could open up new perspectives for the treatment of acute myeloid leukemia - in the form of new combination therapies that use the targeted 'self-defense' of the cancer cells..

这使得科学家能够从多个角度同时观察白血病细胞对p300和CBP抑制的反应。这项基础研究的结果可能为急性髓系白血病的治疗开辟新视角——通过利用癌细胞的针对性“自我防御”来开发新的联合疗法。

The translational research work is funded as part of the Emmy Noether Program of the German Research Foundation (DFG). As part of the Collaborative Research Center 1292, scientists from the Mainz University Medical Center and external cooperation partners in Frankfurt, Greifswald and Cambridge are investigating the causes of inefficient immune responses in tumors and chronic infections with the aim of developing new immunotherapeutic therapies..

这项转化研究工作作为德国研究基金会 (DFG) 艾米·诺特计划的一部分获得资助。在协作研究中心 1292 的框架下，美因茨大学医学中心的科学家以及法兰克福、格赖夫斯瓦尔德和剑桥的外部合作伙伴正在研究肿瘤和慢性感染中免疫反应低效的原因，旨在开发新的免疫治疗疗法。

Note: This article has been translated using a computer system without human intervention. LUMITOS offers these automatic translations to present a wider range of current news. Since this article has been translated with automatic translation, it is possible that it contains errors in vocabulary, syntax or grammar.

请注意：本文已使用计算机系统进行翻译，未经过人工干预。LUMITOS 提供这些自动翻译的文章以展示更广泛的时事新闻。由于本文是通过自动翻译系统翻译的，因此可能会包含词汇、句法或语法方面的错误。

The original article in German can be found .

德语原文可以在以下位置找到。

here

这里

。

Original publication

首次出版

Markus Meyerhöfer, Yawen Zhou, Aaron Gallego-Crespo , Viral Shah, Malte Behrendt, Maria Saura-Pañella, Björn Häupl, Oleksandr Todoriuk, ... George Vassiliou, Brian Huntly, Michael Kühn, Falk Butter, Thomas Oellerich, Daniel Sasca. Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML, Blood (2026).

Markus Meyerhöfer, 周雅文, Aaron Gallego-Crespo, Viral Shah, Malte Behrendt, Maria Saura-Pañella, Björn Häupl, Oleksandr Todoriuk, ... George Vassiliou, Brian Huntly, Michael Kühn, Falk Butter, Thomas Oellerich, Daniel Sasca。抑制p300/CREBBP催化活性驱动AML中依赖上下文的转录激活，《血液》（2026）。

https://www.bionity.com/en/news/1188467/protein-inhibition-can-weaken-leukemia-cells.html

https://www.bionity.com/zh/news/1188467/蛋白质抑制可削弱白血病细胞.html

Master hijackers: uncovering how leukaemia disarms the body’s defences

白血病劫持大师：揭示白血病如何解除身体的防御系统

Microscopic vesicles released from leukaemia tumours and their surrounding cells prove critical in obstructing the body’s ability to fight cancer

白血病肿瘤及其周围细胞释放的微小囊泡被证明会阻碍人体抵抗癌症的能力，这一点至关重要。

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