糖质(glycan)是生命四大基本生物大分子之一,在细胞识别、信号转导、免疫调控和结构支持等多种生理过程中发挥关键作用。历史上,糖质曾常被统称为“碳水化合物”(carbohydrates),这一名称源于其经典化学表达形式Cx(H2O)n;尽管糖质研究可追溯至19世纪,但与蛋白质和核酸相比,糖质科学的发展长期相对滞后。其根本原因在于:糖质太过复杂,一直缺乏有效的研究手段。糖质的生物合成并不像DNA、
我们吃进身体里的糖去哪了?对于这一问题,教科书上会告诉我们,一部分糖用于能量生成,而多余的糖则转化为糖原,储存在肝脏和肌肉中。当身体需要能量供给时,糖原又会被分解为葡萄糖。糖原代谢过程受到一系列酶的精密调控。而过量糖原与许多常见的疾病相关,例如糖尿病、肥胖、肝脏疾病和心脏病。此外,糖原储存疾病是一类罕见的遗传性疾病,患者体内糖原的合成或分解出现异常,这一疾病目前几乎没有治疗选项。最近,《自然》杂志
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