行业观察

AbstractColorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Gut microbiota, including fungal species, are increasingly implicated in CRC progression, while the mo

AbstractDespite variations in appearance, we recognize objects robustly. Neuronal populations responding to objects presented under varying transformations form object manifolds, and hierarchically or

AbstractAttention Deficit Hyperactivity Disorder (ADHD) affects 5-7% of children worldwide, yet diagnosis continues to rely on clinical-behavioral assessments. The theta/beta ratio (TBR) derived from

AbstractMost microbiome research focusses on the taxonomic composition at the species level to understand the impact of environmental factors, but intraspecific diversity has largely been ignored. To

AbstractTFIIH is an essential transcription initiation factor for RNA polymerase II (RNApII). This multi-subunit complex comprises two modules that are physically linked in S. cerevisiae by the subuni

AbstractMonkeys are widely used as model organisms for human vision and cognition. While their anatomy and physiology strongly correspond to humans, it is unclear to what extent their perception match

Abstract Many tropical bird species have restricted elevational distributions, potentially limited by how environmental conditions affect physiological processes. While some studies have examined adul

Takashi HirashimaToshiya Endo Faculty of Life Sciences and the Protein Dynamics Institute, Kyoto Sangyo University, Japan; Biological membranes are masterpieces of cellular architecture. Composed of l

Children’s Hospital of PhiladelphiaMay 8 2026 Researchers from Children's Hospital of Philadelphia (CHOP), in collaboration with colleagues across the country, found that more than one in four pediatr

Aging-USMay 8 2026 A new research paper was published in Volume 18 of Aging-US on April 24, 2026, titled "The BHARAT study: a multi-modal, multi-omics investigation of aging signatures in the Indian p

我们的双手每天要完成成千上万次精细动作——打字、握杯、系鞋带、捏住一支笔。但假如手指深处的屈肌腱断了，即便手术缝得再好，也可能因为一个让人头疼的后果而前功尽弃：肌腱周围粘连。 简单说，就是肌腱在愈合过程中跟旁边的组织“长”在了一起。结果呢？手指伸不直、弯不到位，用力还会疼。严重时，医生只能再做一次手术去“刮”开粘连组织，但效果有限，还可能越做越糟。 目前还没有被广泛接受的预防产品,临床医生和患者最

骨关节炎（OA）以进行性软骨退变为主要特征，且自身修复能力有限。基质血管组分（SVF）移植在再生受损关节组织方面展现出潜力；然而，病变的微环境会损害SVF的干性，从而制约治疗效果。 2026年4月20日，空军军医大学张大伟、Wu Haining、中山大学何留民共同通讯在Advanced Science（IF=14.1）在线发表题为Self-Assembling Hybrid Hydrogel Re

一氧化氮（NO）可通过改善肿瘤缺氧、阻断 DNA 修复，发挥抗放射抵抗肿瘤的作用，但其非特异性毒性限制了临床应用。 2026年4月22日，吉林大学Xue Fuxin、山东第一医科大学Li Yanze共同通讯在Advanced Science（IF=14.1）在线发表题为A Radioresistant-Tumor-Targeted Nanoparticle for X-Ray-Controlled

细胞表面的受体（如EGFR、HER2）是细胞接收外界信号的关键“天线”。它们需要两两配对（二聚化）才能向细胞内传递生长指令。如果受体异常活跃或配对时间过长，会驱使细胞无限增殖，导致癌症。传统单分子追踪使用有机荧光染料，但在激光照射下几十秒内就会“烧毁”（光漂白），科学家只能拍到零散快照，无法全程观察受体从激活到完成信号传递的完整过程。Broad研究所的新技术使用“上转换纳米颗粒”——内部掺杂稀土离

RIG-I样受体（RLRs）通过感知病毒RNA对抗病毒先天免疫至关重要。尽管液液相分离（LLPS）已成为微调免疫信号传导的关键机制，但它在病毒RNA初始感知中的作用仍不充分。 2026年4月28日，山东大学高成江、郑义、香港大学袁硕峰共同通讯在Nature Communications（IF=15.7）在线发表题为CSDE1 promotes viral immune evasion throug