行业观察

AI models may amplify bias in psychiatric aggression predictions

Centre for Addiction and Mental HealthApr 7 2026 A first-of-its-kind study led by researchers at the Centre for Addiction and Mental Health (CAMH) has found that artificial intelligence (AI) models us

发布时间:2026-04-07来源:news-medical
Can diet influence thyroid disease? A major review points to Mediterranean-style eating

By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Apr 7 2026 A major review challenges thyroid diet myths and shows how nutrient-rich, evidence-based eating patterns may better support thyroid

发布时间:2026-04-07来源:news-medical
Biomaterials:中国海洋大学刘雅团队研究设计细菌-纳米材料杂化体系重塑免疫抑制微环境以增强抗肿瘤治疗效果

细菌疗法凭借细菌固有的肿瘤靶向性与免疫调控能力,为重塑“冷”肿瘤的免疫抑制微环境提供了极具前景的治疗策略。通过对细菌进行基因工程改造,可借助同步裂解回路或外源性物理刺激(如光热、磁热手段),使其在肿瘤部位精准、持续地释放免疫激活因子。然而,肿瘤微环境(缺氧与酸性环境)会干扰基因表达效率,且细菌代谢产物(丁酸、乳酸)存在潜在促瘤风险。 2026年3月27日,中国海洋大学刘雅唯一通讯在Biomater

发布时间:2026-04-08来源:iNature
Biomaterials:北京大学江东团队研究利用去核间充质干细胞来源的细胞质体靶向递送线粒体以治疗软骨缺损

关节软骨自身修复能力有限,且易受局部炎症与代谢紊乱的影响,其再生是一大难题。线粒体质量控制(MQC)对维持软骨细胞分化与代谢稳态至关重要,然而靶向线粒体质量控制的治疗策略仍鲜有研究。 2026年3月28日,北京大学江东唯一通讯在Biomaterials 上在线发表题为CytoplastCXCR4: An enucleated self-eliminating and mitochondria de

发布时间:2026-04-08来源:iNature
Cell Metab:南方医科大学曹雄/赵久波团队表面肠道微生物群通过重塑肠脑能量代谢来缓解抑郁

尽管外周脑串扰调节能量代谢,但它在抑郁症中的作用仍不清楚。目前常用的抗抑郁药大多作用于大脑中的单胺类神经递质,但往往起效缓慢,伴随一系列副作用,且复发率居高不下。 2026年3月31日,南方医科大学曹雄、赵久波共同通讯在Cell Metabolism(IF=30.9)在线发表题为The gut microbiota alleviates depression by remodeling gut-b

发布时间:2026-04-08来源:iNature
PNAS:找到控制血管弹性的“开关”!苏州大学杨华乾/高芹芹团队锁定一个关键蛋白,关闭它可能预防动脉瘤

离子通道是仅次于G蛋白偶联受体的第二大临床药物靶点。动脉瘤性疾病对人类生命构成重大威胁,其治疗的新型药物靶点仍有待探索。 2026年3月27日,苏州大学杨华乾 ,高芹芹,Li Zhu和纽约大学William A. Coetzee共同通讯在PNAS 在线发表题为CALHM5 deficiency alleviates aortic aneurysm by regulating smooth musc

发布时间:2026-04-08来源:iNature
Cell子刊:卵巢癌免疫“刹车”失灵怎么办?华中科技大学研究团队找到替代“刹车”B7H3,为特定患者提供新出路

免疫检查点阻断(ICB)疗法在卵巢癌(OC)中疗效有限。PTEN 缺失是卵巢癌常见的驱动因素,但其对 ICB 疗效的影响尚不明确。 2026年3月31日,华中科技大学Xia Yu、刘丹、高庆蕾共同通讯在Cell Reports 在线发表题为PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum

发布时间:2026-04-08来源:iNature
Science:六十年争议尘埃落定!新研究直接观测视觉信息流,证实Hubel-Wiesel模型

一场持续六十年、关于哺乳动物视觉感知基本机制的科学争议现已解决。慕尼黑工业大学(TUM)的研究人员成功观测到了从神经元到神经元的视觉信息流。他们的发现证实了David Hubel和Torsten Wiesel在1981年获得诺贝尔奖的模型的有效性,该模型在某些方面此前一直存在争议。 在1960年代,Hubel和Wiesel提出了一个模型,即Hubel-Wiesel模型,根据该模型,视觉感知是大脑中

发布时间:2026-04-08来源:生物谷
Immunity:高脂饮食几天就能“干掉”肠道护卫军?科学家发现关键机制

全球肥胖和超重人口已超过20亿,炎性肠病、结直肠癌等慢性疾病的发病率也持续攀升,这些疾病与肠道炎症密切相关,而饮食结构改变,尤其是高脂饮食的普及,被认为是重要推手。然而,高脂饮食究竟如何快速“攻击”肠道免疫系统,此前并不清楚。 近日,一篇发表在国际杂志Immunity上题为“High-fat diet causes rapid loss of intestinal group 3 innate l

发布时间:2026-04-08来源:生物谷
Xuebijing injection reduces inflammation and ferroptosis in acute lung injury

Chinese Academy of SciencesApr 7 2026 Using an LPS-induced ALI mouse model and LPS-stimulated alveolar macrophages, they found XBJ reduced inflammatory cytokine surges, preserved alveolar barrier inte

发布时间:2026-04-07来源:news-medical
Study questions benefits of fish oil after mild brain injuries

Medical University of South CarolinaApr 7 2026 A first-of-its-kind study led by the Medical University of South Carolina raises questions about the value of fish oil supplements for people with repeti

发布时间:2026-04-07来源:news-medical
Neighborhood conditions linked to cellular aging and health disparities

New York UniversityApr 7 2026 There's a growing consensus that your zip code is a strong predictor of your health and lifespan. Now, researchers at NYU School of Global Public Health have determined t

发布时间:2026-04-07来源:news-medical
Childhood trauma inspires research into brain repair and recovery

University of the WitwatersrandApr 7 2026 What began as a child's encounter with trauma has grown into a research programme committed to understanding recovery. When she was in Grade 5, Dr Gillian Mah

发布时间:2026-04-07来源:news-medical
Brain study reveals sender and receiver roles in default mode network

Chinese Academy of SciencesApr 7 2026 The default mode network (DMN) is a distributed set of interconnected brain regions that has long been associated with internally oriented cognition such as remem

发布时间:2026-04-07来源:news-medical
Early genetic signals connect diabetes subgroups to heart disease risk

Lund UniversityApr 7 2026 A growing body of research shows that diabetes can be stratified into five different subgroups. Researchers at Lund University have now investigated whether a person's geneti

发布时间:2026-04-07来源:news-medical