University of Illinois at Urbana-ChampaignApr 7 2026 By tagging neurons with molecular "barcodes," researchers mapped connections among thousands of neurons in the mouse brain with unprecedented speed
Cornell UniversityApr 7 2026 Cornell University scientists have taken a major step toward developing a safe, reversible, long-acting and 100% effective nonhormonal male contraceptive, considered the h
Centre for Addiction and Mental HealthApr 7 2026 A first-of-its-kind study led by researchers at the Centre for Addiction and Mental Health (CAMH) has found that artificial intelligence (AI) models us
By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Apr 7 2026 A major review challenges thyroid diet myths and shows how nutrient-rich, evidence-based eating patterns may better support thyroid
细菌疗法凭借细菌固有的肿瘤靶向性与免疫调控能力,为重塑“冷”肿瘤的免疫抑制微环境提供了极具前景的治疗策略。通过对细菌进行基因工程改造,可借助同步裂解回路或外源性物理刺激(如光热、磁热手段),使其在肿瘤部位精准、持续地释放免疫激活因子。然而,肿瘤微环境(缺氧与酸性环境)会干扰基因表达效率,且细菌代谢产物(丁酸、乳酸)存在潜在促瘤风险。 2026年3月27日,中国海洋大学刘雅唯一通讯在Biomater
关节软骨自身修复能力有限,且易受局部炎症与代谢紊乱的影响,其再生是一大难题。线粒体质量控制(MQC)对维持软骨细胞分化与代谢稳态至关重要,然而靶向线粒体质量控制的治疗策略仍鲜有研究。 2026年3月28日,北京大学江东唯一通讯在Biomaterials 上在线发表题为CytoplastCXCR4: An enucleated self-eliminating and mitochondria de
尽管外周脑串扰调节能量代谢,但它在抑郁症中的作用仍不清楚。目前常用的抗抑郁药大多作用于大脑中的单胺类神经递质,但往往起效缓慢,伴随一系列副作用,且复发率居高不下。 2026年3月31日,南方医科大学曹雄、赵久波共同通讯在Cell Metabolism(IF=30.9)在线发表题为The gut microbiota alleviates depression by remodeling gut-b
离子通道是仅次于G蛋白偶联受体的第二大临床药物靶点。动脉瘤性疾病对人类生命构成重大威胁,其治疗的新型药物靶点仍有待探索。 2026年3月27日,苏州大学杨华乾 ,高芹芹,Li Zhu和纽约大学William A. Coetzee共同通讯在PNAS 在线发表题为CALHM5 deficiency alleviates aortic aneurysm by regulating smooth musc
免疫检查点阻断(ICB)疗法在卵巢癌(OC)中疗效有限。PTEN 缺失是卵巢癌常见的驱动因素,但其对 ICB 疗效的影响尚不明确。 2026年3月31日,华中科技大学Xia Yu、刘丹、高庆蕾共同通讯在Cell Reports 在线发表题为PTEN loss drives B7H3 upregulation via the mTORC2/FOXO/c-Myc axis to promote tum
一场持续六十年、关于哺乳动物视觉感知基本机制的科学争议现已解决。慕尼黑工业大学(TUM)的研究人员成功观测到了从神经元到神经元的视觉信息流。他们的发现证实了David Hubel和Torsten Wiesel在1981年获得诺贝尔奖的模型的有效性,该模型在某些方面此前一直存在争议。 在1960年代,Hubel和Wiesel提出了一个模型,即Hubel-Wiesel模型,根据该模型,视觉感知是大脑中
全球肥胖和超重人口已超过20亿,炎性肠病、结直肠癌等慢性疾病的发病率也持续攀升,这些疾病与肠道炎症密切相关,而饮食结构改变,尤其是高脂饮食的普及,被认为是重要推手。然而,高脂饮食究竟如何快速“攻击”肠道免疫系统,此前并不清楚。 近日,一篇发表在国际杂志Immunity上题为“High-fat diet causes rapid loss of intestinal group 3 innate l
Chinese Academy of SciencesApr 7 2026 Using an LPS-induced ALI mouse model and LPS-stimulated alveolar macrophages, they found XBJ reduced inflammatory cytokine surges, preserved alveolar barrier inte
Medical University of South CarolinaApr 7 2026 A first-of-its-kind study led by the Medical University of South Carolina raises questions about the value of fish oil supplements for people with repeti
New York UniversityApr 7 2026 There's a growing consensus that your zip code is a strong predictor of your health and lifespan. Now, researchers at NYU School of Global Public Health have determined t
University of the WitwatersrandApr 7 2026 What began as a child's encounter with trauma has grown into a research programme committed to understanding recovery. When she was in Grade 5, Dr Gillian Mah
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