行业观察

AbstractFever is a hallmark of malaria. Several studies have linked febrile temperatures to reduced parasite viability, but also to increased cytoadhesion, a key driver of pathology. However, differen

AbstractRAB5-GTP activation of the multiprotein VPS34 complex II (VPS34-CII) is critical for endosomal sorting and maturation, phagocytosis, and receptor downregulation. RAB5-GTP activates VPS34-CII,

AbstractTo survive exposure to heat stress (HS), organisms activate stress response genes and repress constitutive gene expression, thereby preventing the accumulation of potentially toxic RNA and pro

AbstractIn mouse superior colliculus (SC), neurons are robustly tuned to motion direction and orientation, but it remains controversial whether these preferences form global maps or are arranged in a

AbstractAdaptive evolution enables species to survive and thrive under changing environmental conditions. In the face of accelerating global climate change, thermal stress represents a major challenge

AbstractSrc-family kinases (SFKs) regulate proliferation in colonic epithelial cells (CECs), but the mechanisms that restrain their activity remain poorly defined. We identify Src-like adaptor protein

Abstract Sharing positive and negative experiences at lab meetings can make a career in science a little less hard, a little more pleasant, and a little more human. Main text Most scientists are part

Geoffroy Laumet Department of Physiology, Michigan State University, United States; Neuropathic pain develops when nerve damage causes the pain-sensing pathways in the nervous system to become hyperse

Hilal WehbiIsabelle Broutin Laboratoire CiTCoM, Faculté de Santé, Université Paris Cité and CNRS, France; We have become used to treating bacterial infections with antibiotics, but in recent decades t

Zhao WangYang Fu Department of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, China; Mammals have communities of microbes in t

Jessica L MaltmanJavier González-Maeso Biomedical Sciences Graduate Program, Virginia Commonwealth University School of Medicine, United States; Department of Pharmacology and Toxicology, Virginia Com

近年来，中国出台各类利好商业航天产业发展的相关政策。一方面，从商业航天需求端入手，扩大政府采购商业航天产品和服务范围；另一方面，从商业航天供给端入手，通过政府和社会资本合作模式（PPP）等多种创新模式，鼓励政府、国内外企业投资各类航天活动，延伸航天产业链条。例如，2024年发布的《商业航天技术创新专项支持计划》提出，提供研发补贴（最高1亿元/项目），聚焦液氧甲烷发动机、卫星激光通信、在轨服务机器人

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各有关单位： 全球生物制造产业正经历从传统经验驱动向智能化、精准化转型的关键阶段。菌种是生物产业的命脉和核心竞争力，是生物企业技术创新和提高竞争力的有力保障，人工智能、合成生物学、基因编辑等前沿技术的深度融合，为微生物发酵菌种的选育与改造带来了革命性的机遇。 通过分析菌株基因组序列，预测其潜能，有针对性地激活和筛选；通过合成生物学技术，将目标基因簇在异源宿主中表达，实现产量优化和新化合物发现；而A