行业观察

Abstract Polyphosphate (polyP) exists in all life forms; however, its biological functions in metazoans are understudied. Here, we explored Drosophila, to our knowledge, as the first genetic model to

AbstractAlpha-band neural oscillations (8–13 Hz) are theorized to phasically inhibit visual processing based, in part, on results showing that pre-stimulus alpha phase predicts detection (i.e., hit ra

Abstract Although division of labor as a means to increase productivity is a common feature in animal social groups, most previous studies have focused almost exclusively on eusocial insects with extr

Abstract GID/CTLH-type E3 ligases assemble into conserved ring-shaped architectures built from repeating LisH-CTLH-CRA modules, yet the molecular rules that enforce their highly specific subunit arran

Abstract The positioning of limbs along the anterior-posterior axis varies widely across vertebrates. The mechanisms controlling this feature remain to be fully understood. For over 30 years, it has b

Abstract The identification of cell types remains a major challenge. Even after a decade of single-cell RNA sequencing (scRNA-seq), reasonable cell type annotations almost always include manual non-au

Ana S RamírezCamilo Perez Department of Biochemistry and Molecular Biology, University of Georgia, United States; Complex Carbohydrate Research Center, University of Georgia, United States; From proka

By Dr. Priyom Bose, Ph.D.Reviewed by Lauren HardakerApr 8 2026 New evidence suggests common viral infections may shape dementia risk, while vaccination and antiviral therapies could offer a surprising

对于激素受体阳性的乳腺癌患者来说，芳香化酶抑制剂是控制肿瘤的重要武器。它通过抑制雌激素生成来阻断肿瘤生长信号，但雌激素的缺失也让骨骼和肌肉付出代价：骨量流失加速、肌肉无力、脂肪堆积。这些问题不仅影响生活质量，还可能导致患者中断治疗，反而影响预后。有没有一种既能保护骨骼肌肉、又不增加身体负担的方法？ 近日，Nat Commun上发表的研究给出了新思路。他们发现，一种名为低强度振动的物理干预，每天仅需

小细胞肺癌（SCLC）神经周围浸润（PNI）发生率高，这一临床特征与不良预后密切相关。 2026年3月28日，上海交通大学钟华、杭州师范大学王永杰共同通讯在Cell Reports 在线发表题为Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic repro

全球每年仅肾癌一种就有超过40万新发病例，而胆管癌、间皮瘤和葡萄膜黑色素瘤虽然相对少见，却以高度侵袭性和极差的治疗响应著称，这四种看似不相关的癌症其实藏着一个共同的“软肋”，它们都频繁携带BAP1基因的失活突变。BAP1究竟是何方神圣？它失活后为何能让癌细胞如此嚣张？ 日前，一篇发表在国际杂志Science Translational Medicine上题为“Uncovering BAP1 deu

免疫疗法在几种癌症中取得了持久的疗效，但在难治性肝细胞癌(HCC)中疗效有限。肝癌细胞逃避免疫识别和限制免疫检查点阻断(ICB)功效的机制尚未完全确定。 2026年4月2日，中山大学周仲国、陈东萍、赵明共同通讯在Journal of Clinical investigation（IF=13.6）在线发表题为Tescalcin is a phagocytic checkpoint driving i

CAR-T 细胞疗法（嵌合抗原受体 T 细胞疗法）早已在白血病、淋巴瘤等血液癌症治疗中取得里程碑式的突破，让无数复发难治的患者实现了长期缓解甚至临床治愈。但在占比超 90% 的实体瘤面前，这款 “抗癌神药” 却始终步履维艰，核心卡在两大无法绕开的难题上： 一是实体瘤细胞的抗原高度异质性，缺乏像血液癌中 CD19 那样统一、稳定的广谱靶点，极易因抗原丢失出现耐药； 二是实体瘤外围往往包裹着致密的纤维

酪酸梭菌CGMCC0313-1产业化及临床应用现状 褚传莲1 张笛2 1 山东省研究型医院协会消化病学分会副主任委员，山东省医学会消化分会炎症性肠病学组副组长 2 青岛市医用与食用微生态制品研发重点实验室，医用微生态制品开发国家地方联合工程研究中心 【摘要】酪酸梭菌（Clostridium butyricum）CGMCC0313-1是一种能够产生丁酸的专性厌氧益生菌，在维持肠道微生态平衡、调节免疫

UFMylation 是近年发现的一种类泛素化修饰，由 E3 连接酶UFL1介导，在肿瘤中发挥环境依赖性作用，但其在肺腺癌（LUAD）中的底物与功能尚不明确。 2026年3月25日，暨南大学刘同征、王少华、周洋、Song Yang共同通讯在Cell Reports 在线发表题为UFMylation-dependent inhibition of AKT signaling by PHLDA3 in